Nanofat Fillers: The New, Natural Treatment for Lines & Wrinkles

As we age the face loses volume, causing sagging and wrinkling that adds years to our appearance. While dermal fillers are an excellent temporary solution, transferring the patient’s own “nano fat” from other areas of the body can provide a more permanent solution. The BeautiFill process enables top Manhattan dermatologist Dr. Goldenberg to extract living fat cells from the body and inject them into the face to fill wrinkles and restore facial volume.

Using the patient’s own nanofat as a filler is non-surgical and 100% natural.  By transferring tiny fat particles from one area of the patient’s body to another, nanofat fillers are capable of effectively reversing signs of the aging process such as fine lines, wrinkles, hollow contours, and thinning lips.

Dr. Gary Goldenberg is among the first providers in Manhattan to offer state-of-the-art autologous fat transfer as an all natural alternative to synthetic dermal fillers – as a means of restoring volume to hollow areas and filling lines and wrinkles. At Goldenberg Dermatology we use the advanced BeautiFill procedure that extracts living fat cells from unwanted areas of the body, after which they are purified and injected into areas of the face or body needing volume.

The Science of Nanofat Fillers

Nanofat Grafting is a form of “autologous fat transfer”, the process by which volume is added to various areas on a person’s body, by using their own fat tissue. Nanofat grafting may also be referred to by the names micro-fat grafting or Autologous Lipocyte Micronized Injection (ALMI).

Nano Fat Grafting refers to the process by which a small amount of a patient’s fat is removed from their body and then filtered down into incredibly small particles of fat that are used in the procedure. Goldenberg Dermatology has an outstanding track record of treating our patients using only the latest and most effective procedures. Now, nanofat fillers join the many other innovative aesthetic procedures available at our Manhattan dermatology practice.

In addition to acting as a filler, in clinical studies Nanofat Grafting has also been shown to stimulate architectural changes to the collagen and elastin of the treatment area, thus resulting in the actual regeneration of tissues.

The Nanofat Filler Process

The nanofat filler procedure begins with the innovative BeautiFill process, a state-of-the-art approach to harvesting the patient’s own fat cells. Unlike traditional fat harvesting methods that can damage cells, BeautiFill uses laser technology to gently dislodge fat cells while simultaneously tightening the skin at the donor site. This precision approach significantly increases the viability of harvested cells, with studies showing survival rates of up to 95% compared to 50-60% with conventional techniques.

Once harvested, the fat undergoes a specialized emulsification and filtration process to create what dermatologists refer to as “nanofat” – essentially pure adipose  cells and growth factors with the larger fat components removed. This refined material is substantially different from traditional fat grafts, featuring particles small enough to be injected through fine needles similar to those used with conventional dermal fillers. The processing techniques preserve the regenerative properties of the fat while creating a smooth, injectable substance ideal for treating fine lines and delicate areas.

The injection phase uses precise technique to place the nanofat in various areas of the face, depending on the specific concerns being addressed. For superficial lines, injections target the upper dermis, while deeper folds may require placement in deeper tissue layers. Drs. Gary and Kristina Goldenberg may use cannulas rather than needles for certain areas, reducing the risk of bruising and vascular complications while ensuring even distribution of the nanofat material.

Unlike synthetic fillers which typically take less than an hour, the complete BeautiFill nanofat procedure requires approximately 2 to 3 hours from harvest to injection. This additional time investment delivers substantial benefits—the procedure addresses both the treatment area and improves contour at the harvest site (typically the abdomen, flanks, or thighs), essentially providing two aesthetic improvements in a single session. Patients leave with detailed aftercare instructions to optimize cell survival and longevity of results.

Benefits of Nanofat Fillers

The primary advantage of nanofat fillers lies in their regenerative properties that go far beyond the temporary volumizing effects of synthetic dermal fillers. The adipose-derived stem cells and growth factors contained in the nanofat actively promote collagen synthesis, improve microcirculation, and enhance skin quality through cellular regeneration. This creates progressive improvement over time rather than the immediate but static results typical of hyaluronic acid fillers.

Longevity represents another significant benefit, with nanofat filler results often lasting up to 5 years compared to the 6 to18 months typically seen with synthetic dermal fillers. This extended duration occurs because a percentage of the transferred cells establish a permanent blood supply and integrate into the surrounding tissues. Research published in the Aesthetic Surgery Journal demonstrates that approximately 50-70% of properly processed and injected nanofat remains viable long-term, substantially reducing the need for maintenance treatments.

Nanofat fillers also virtually eliminate the risk of allergic reactions or biocompatibility issues since the material comes from the patient’s own body. This autologous nature makes nanofat an excellent option for patients who have experienced sensitivity to synthetic fillers or those with autoimmune conditions that might react to foreign materials. The risk profile is particularly favorable for treating delicate areas like the tear troughs, where conventional fillers sometimes cause prolonged swelling or Tyndall effect (bluish discoloration).

Beyond wrinkle correction, nanofat delivers impressive improvements in overall skin quality that synthetic dermal fillers do not. Patients typically report enhanced skin texture, improved elasticity, and reduced pore size in treated areas – in addition to the filler benefits. These improvements in skin vitality offer long-term, natural-looking rejuvenation that comes from improved skin health rather than simply temporarily filling lines.

Uses of Nanofat Fillers

At our Manhattan practice, we offer nanofat filler as a means of restoring a more youthful appearance to areas of wrinkles and lines, volume loss and/or thinning skin.

In addition to helping restore facial volume to the skin, nanofat filler has also proven to be effective for improving contours in other areas of the body. Nanofat grafting has also been demonstrated to aid in the healing process, and can help improve the appearance of scarring. These incredible properties of the nanofat grafting procedure are believed to stem from both the reduction of inflammation and the increased blood supply to the tissues of the treatment area.

Board certified Manhattan dermatologist Dr. Goldenberg has used nanofat fillers with great success to provide reduction of fine lines, wrinkles, perioral rhytids, thinning lips, and deep lines on the face and neck. Nanofat grafting is also highly effective for providing rejuvenation to the forehead, and can also treat radiated tissue, acne scars, and scars in general.

Nanofat fillers can also often used in combination with our laser skin rejuvenation treatments – including the MiXto Fractionated laser at our Manhattan aesthetic dermatology practice. The MiXto is a laser retexturing treatment that can smooth out the surface of the skin and rejuvenate the overall appearance – also with very minimal downtime.

Good Candidates for Nanofat Fillers

Ideal candidates for nanofat fillers include individuals seeking natural-looking correction of moderate to severe facial volume loss, particularly in areas where conventional fillers might look artificial or create complications. Patients concerned about the temple region, tear troughs, and deep nasolabial folds often achieve exceptional results with nanofat, as these areas benefit from the structural support and regenerative effects that synthetic options cannot provide.

Nanofat fillers also present an excellent option for patients with previous negative experiences using synthetic dermal fillers, such as those who have developed granulomas, experienced migration of product, or who have been dissatisfied with the more dramatic appearance of conventional fillers. Similarly, individuals with known sensitivities to hyaluronic acid or other synthetic filler components find nanofat provides a biocompatible alternative without sacrificing effectiveness.

At Goldenberg Dermatology in Manhattan, Drs. Goldenberg emphasize that both nanofat and synthetic dermal fillers like Juvéderm have their place in a comprehensive approach to facial rejuvenation. For patients seeking more dramatic and immediate – but temporary – correction of fine lines traditional hyaluronic acid fillers often remain the most practical option. Our Manhattan dermatologists can also combine both approaches for optimal results—using nanofat for areas benefiting from regenerative effects and synthetic fillers for precise refinement or areas with minimal available fat.

Candidates should have realistic expectations regarding both the procedure and recovery. Nanofat treatments typically involve some initial swelling that synthetic fillers might not cause, and the final results continue to develop gradually over several months as the regenerative effects progress. The ideal patient for nanofat fillers values this natural progression and understands that while the recovery may be slightly longer than with synthetic options, the long-term benefits and reduced maintenance requirements often justify this initial investment.

Nanofat Fillers – Manhattan

Nanofat fillers are a safe, effective, long-lasting and 100% natural method of reversing the signs of aging – without surgery or the use of temporary synthetic fillers. For more information about the benefits of nanofat fillers, contact Goldenberg Dermatology in Manhattan today – and become a younger looking, more beautiful version of YOU!

Dr. Goldenberg is one of the first and only dermatologists in the entire Manhattan and New York, NY area to offer cutting-edge BeautiFill nanofat grafting.  If you’re considering facial rejuvenation top Manhattan Board Certified Dermatologist Dr. Gary Goldenberg, can help you decide whether nanofat fillers are right for your antiaging and aesthetic needs.

Manhattan NanoFat Fillers: 212-405-8202